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Adenoviral expression of the Nephroblastoma overexpressed gene product (CCN3/NOV) induces apoptosis and inhibits epithelial-to-mesenchymal transition (EMT) in hepatocytes in vitro…

E Borkham-Kamphorst, S Huss, E Van de Leur, U Haas, R Weiskirchen · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
977617
CareLit-ID
Jahr
2012
Publikation
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
E Borkham-Kamphorst, S Huss, E Van de Leur, U Haas, R Weiskirchen
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1295733

Zusammenfassung

CCN3/NOV encoded by the Nephroblastoma overexpressed gene represents a matricellular protein of the CCN family. These proteins comprise six different secreted proteins associating specifically with the extracellular matrix [1]. CCN proteins lack specific high-affinity receptors but signal through integrins and proteoglycans and regulate crucial biological processes in liver including fibrosis [2]. Previously we have demonstrated that CCN3 expression increases dramatically during activation of hepatic stellate cells (HSC) and in models of experimental liver fibrosis [3]. Notably, suppression of CCN3 enhanced expr…

Schlagworte

BDL CCN2 CCN3 EMT adenovirus gene transfer animal models. apoptosis hepatic stellate cells hepatocytes inflammation liver fibrosis Connective Tissue Growth Factor Connective Tissue Architecture Caspase 3 Zeitschrift für Gastroenterologie