CareLit Fachartikel
Extracellular matrix induced signaling and TGF-β regulate Caveolin–1 expression in hepatocytes
C Meyer, Y Liu, F Schindler, J Dzieran, S Dooley · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
977620
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
A major obstacle for the use of primary hepatocytes in research and drug testing is their tendency to dedifferentiate towards a mesenchymal phenotype during culture. This process is driven by integrin/FAK/Src signaling cascades, which leads to the upregulation of fibroblastoid markers, such as vimentin and N-Cadherin. Caveolin–1 is involved in endocytic processes as well as in the regulation of diverse signaling cascades and has been linked to cancer invasiveness. Culture driven hepatocyte dedifferentiation culminates in a significant increase in Caveolin–1 expression. This is driven by a Src dependent signaling…
Schlagworte
EMT
HCC
Caveolin 1
Observation
Cytokine
Tumor
Zeitschrift für Gastroenterologie
