CareLit Fachartikel
Analysis of cellular origin and degradation pathways of the endocannabinoid 2-arachidonoyl glycerol during liver fibrogenesis
A Wojtalla, MV Singer, T Sauerbruch, A Zimmer, SV Siegmund · Zeitschrift für Gastroenterologie · 2012 · Heft 01
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977622
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Jahr
2012
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Zusammenfassung
BACKGROUND and Aims: We and others have previously shown, that the hepatic endocannabinoid (EC) system becomes activated and plays an important role in liver fibrogenesis. However, cellular origin and mechanisms that lead to increased EC levels (e.g. 2-arachydonoyl glycerol, 2-AG) are unknown. We analysed expression of the major 2-AG-generating enzyme diacylglycerol lipase (DAGL)-beta and the main degrading enzyme monoacylglycerol-lipase (MGL) in different hepatic cell populations as well as in normal and fibrotic mouse livers at different timepoints after bile duct ligation (BDL). Methods: Primary mouse hepatoc…
Schlagworte
2-AG
Endocannabinoids
hepatic stallate cells
liver fibrosis
liver sinusoidal endothelial cells
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Zeitschrift für Gastroenterologie
