CareLit Fachartikel
Soy isoflavone Genistein affects energy metabolism in a steatotic liver model
S Lünse, A Krüger, M Glanemann, G Damm · Zeitschrift für Gastroenterologie · 2012 · Heft 01
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977624
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2012
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Zusammenfassung
Non-alcoholic fatty liver disease (NAFLD) is already the most common chronic liver disease in western countries. The complex metabolic disorder is strongly associated with insulin resistance. Epidemiological studies suggest beneficial effects of the natural soy isoflavone Genistein (GEN) on hepatic energy metabolism. Our aim was to establish a steatotic liver in vitro model to investigate the impact of GEN on energy metabolism focused on insulin signaling. Primary human hepatocytes (PHH) were isolated from resected liver tissues via a two-step collagenase perfusion technique. Steatosis was induced by adding olei…
Schlagworte
energy metabolism
genistein
insulin resistance
isoflavones
steatotic liver
After
Zeitschrift für Gastroenterologie
