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Src kinase Fyn mediates hyperosmolarity-induced Mrp2- and Bsep-retrieval from the canalicular membrane in a cortactin dependent way

R Reinehr, M Cantore, A Sommerfeld, M Becker, D Häussinger · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
977625
CareLit-ID
Jahr
2012
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
R Reinehr, M Cantore, A Sommerfeld, M Becker, D Häussinger
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1295823

Zusammenfassung

Introduction: Hyperosmolarity induces Mrp2-/Bsep-retrieval from the canalicular membrane leading to cholestasis.1,2 The underlying signaling events remained unclear. Methods: Rat livers were perfused with either normo- (305mOsm) or hyperosmolarity (385mOsm) following Mrp2-/Bsep-staining and analyzation of transporter localization. Bile flow was measured by biliary excretion of CDNB-glutathione conjugate in perfused liver and using CLF-secretion in hepatocyte couplets. Results: In perfused rat liver, hyperosmolarity induced within 30min a Mrp2/Bsep-retrieval from the canalicular membrane, which was paralleled by…

Schlagworte

bile acid transport cholestasis osmosignaling Cortactin Association Actin Acetylcysteine Zeitschrift für Gastroenterologie