Detection of highly carcinogenic, exocyclic etheno-DNA-adducts in the liver of children with non-alcoholic fatty liver disease
U Teufel, G Engelmann, C Flechtenmacher, T Peccerella, G Millonig, G Hoffmann, S Mueller, HK Seitz · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Exocyclic etheno-DNA-adducts (edA) are highly carcinogenic DNA-lesions which are formed by the reaction of the lipid peroxidation product 4-hydroxynonenal (4HNE) with DNA 1. Recently, we found a significant correlation between the induction of cytochrome P4502E1 (CYP2E1) and edA in patients with alcoholic liver disease 2. CYP2E1 is also induced in non-alcoholic fatty liver disease (NAFLD) 3, a growing liver disease entity in the Western World not only in adults, but also in children and adolescents. Since NAFLD patients have an increased risk for hepatocellular cancer (HCC) 4, early generation of carcinogenic DN…
