COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS
P Fytili, A Gronert, C Brauner, A Zapf, C Meyer-Heithuis, F Lehner, CP Strassburg, E Jaeckel, MP Manns, C Falk, M Cornberg, H Wedemeyer · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Chronic HCV infection is one of the main indications for liver transplantation (LTx) in developed countries and the reinfection of the graft is almost universal. The differentiation between graft hepatitis due to HCV and rejection is a challenging problem demanding opposing therapeutic strategies. The aim of this study was to investigate if characteristics of regulatory T cells (Tregs) and plasma biomarkers differ in graft hepatitis C and rejection. Methods: 31 patients that underwent LTx were enrolled in a prospective observational study. All patients received protocol liver biopsies and PBMCs and plasma were c…
