CareLit Fachartikel
Impact of genetic concentrative nucleoside transporter variants on interferon/ribavirin therapy response in hepatitis C patients
M Rau, M Weisskopf, J Schmitt, S Russmann, B Müllhaupt, A Geier · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
977630
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: Treatment of HCV infection will change in the near future and direct acting antiviral drugs (DAA) will be added to existing antiviral therapy with peg-interferon-α and ribavirin (RBV). Side effects such as RBV-induced hemolytic anemia will be even worsened in combination with DAAs. Therefore, understanding of genetic host factors determining RBV bioavailability and therapeutic efficacy will remain crucial for individualized treatment. Recent data showed an association between RBV-induced hemolytic anemia and polymorphisms of concentrative nucleoside transporters such as CNT3 (encoded by SLC28A3). Aim: To a…
Schlagworte
HCV
RBV
SVR
concentrative nucleoside transporter
Association
Anemia
Hepatitis
Population
Allele
Zeitschrift für Gastroenterologie
