CareLit Fachartikel
P2Y2 receptor function aggravates acute hepatitis by regulating neutrophil infiltration and hepatocyte survival
K Ayata, M Idzko, P Hasselblatt · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
977632
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Zusammenfassung
Background & Aims: Analysis of the molecular pathways linking inflammation and hepatocyte survival is essential to identify novel therapies for inflammatory liver disease. Release of extracellular ATP and subsequent activation of purinergic P2 receptors (P2R) is increasingly recognized as an important danger signal and mediator of pro-inflammatory responses. We therefore addressed the question whether ATP and P2R serve as major regulators of acute hepatitis. Methods: To address this issue, acute hepatitis was induced in P2R knockout mice and controls by injection of Concanavalin A, an established model of fulmin…
Schlagworte
Extracellular ATP
purinergic receptors
Concanavalin A
hepatocyte apoptosis
Hepatitis
Address
Zeitschrift für Gastroenterologie
