Xanthohumol inhibits hepatitis B virus replication in vitro
C Dorn, W Jilg, J Heilmann, C Hellerbrand · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Xanthohumol is the principal prenylated chalcone of the female inflorescences of the hop plant, and it has been shown to have several beneficial biological activities, with its chemopreventive and anti-inflammatory properties being the most extensively investigated. Previously, we have shown that xanthohumol inhibits hepatic inflammation and fibrosis in a murine model of non-alcoholic steatohepatitis as well as the tumorigenicity of hepatocellular carcinoma (HCC) cells in vitro. Chronic hepatitis B virus (HBV) infection is one of the most frequent liver disease worldwide. It harbors a high risk to progress to ci…