THE ENTRY INHIBITOR MYRCLUDEX-B EFFICIENTLY BLOCKS VIRAL SPREADING IN VIVO IN HUMAN LIVER CHIMERIC uPA/ SCID MICE PREVIOUSLY INFECTED WITH HEPATITIS B VIRUS
M Lütgehetmann, M M´Barek, T Volz, L Allweiss, M Helbig, A Alexandrov, AW Lohse, J Petersen, S Urban, M Dandri · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Antiviral treatments based on interferon-a or polymerase inhibitors are generally notcurative and additional therapeutic strategies interfering with other HBV replicationsteps are needed. We previously demonstrated prevention of de novo HBV infectionby pre-treating uPA/SCID mice with Myrcludex-B, a lipopeptide derived from the HBVpreS1 domain (Nat. Biotech.2008). Aim of this study was to investigate the abilityof Myrcludex-B to block HBV spreading post-infection. Experimental design: humanchimeric uPA/SCID mice were injected with HBV-infectious serum (5×10E7 HBV DNAcopies/mouse). Treatment with Myrcludex-B (2mg/…
