Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes
C Scheurich, I Tóth, V Matzat, S Kummer, S Polywka, T Meyer, T Eiermann, AW Lohse, P Hartjen, J van Lunzen, J Schulze zur Wiesch · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: An important component of a successful immune response is a strong and durable CD4+ T cell response directed against multiple epitopes covering the whole HCV polyprotein. However, few HCV CD4+ epitopes have been characterized in detail so far. Here, we study a set of HCV CD4+ T cell specificities concerning their optimal length, HLA restriction and cross-genotype reactivity. Methods: HCV-specific CD4+ T cells from PBMC from 40 HCV patients with different disease outcome (15 spontaneous resolvers) and healthy controls were in vitro expanded with a set of 24 frequently targeted HCV genotype (GT) 1a 2…
