CareLit Fachartikel
Presence of primary human hepatocytes inhibits expansion of virus-specific CD8+ T cells in vitro
S Ziegler, R Bröring, G Gerken, JF Schlaak, J Timm · Zeitschrift für Gastroenterologie · 2012 · Heft 01
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977638
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Jahr
2012
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Zusammenfassung
Background: A hallmark of chronic infections with hepatotropic viruses such as HBV and HCV is the notoriously weak antiviral immune response by CD8 T cells. It is believed that the liver-specific environment can induce tolerance either by induction of dysfunctional CD8 T cells or by premature death of activated CD8 T cells. Recent reports from mouse models indicate that hepatocytes can act as antigen-presenting cells. Direct antigen presentation by virally infected hepatocytes thus might inhibit the CD8 T cell response. Methods: Primary hepatocytes were isolated from resected liver fragments of patients undergoi…
Schlagworte
Cytokines
After
Antigen-Presenting Cells
Antigen Presentation
Cytokine
Zeitschrift für Gastroenterologie
