Better detection of Hepatocellular Carcinoma by combining Alphafeto-Protein (AFP) and Des-Gamma-Carboxyprothrombin (DCP)
JM Ertle, D Heider, M Wichert, R Küper, JF Schlaak, G Gerken · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction. Hepatocellular Carcinoma (HCC) is the fifth most common tumor worldwide with increasing incidence. Screening and diagnosis depend on ultrasound and the biomarker Alphafetopreotein (AFP), but AFP has a low sensitivity. Aim. The aims of this study were to determine (i) the sensitivity and specificity of AFP, Desgamma-Carboxy-Prothrombin (DCP), and Lens-cullinaris-Antigen (AFP-L3%) within a northern European cohort, (ii) whether the sensitivity could be increased in combined measurement and (iii) whether other factors alter these results.Materials and Methods. We performed a single-center, prospective…