CareLit Fachartikel

Better detection of Hepatocellular Carcinoma by combining Alphafeto-Protein (AFP) and Des-Gamma-Carboxyprothrombin (DCP)

JM Ertle, D Heider, M Wichert, R Küper, JF Schlaak, G Gerken · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
977640
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Jahr
2012
Publikation
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DOI
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Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
JM Ertle, D Heider, M Wichert, R Küper, JF Schlaak, G Gerken
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771

Zusammenfassung

Introduction. Hepatocellular Carcinoma (HCC) is the fifth most common tumor worldwide with increasing incidence. Screening and diagnosis depend on ultrasound and the biomarker Alphafetopreotein (AFP), but AFP has a low sensitivity. Aim. The aims of this study were to determine (i) the sensitivity and specificity of AFP, Desgamma-Carboxy-Prothrombin (DCP), and Lens-cullinaris-Antigen (AFP-L3%) within a northern European cohort, (ii) whether the sensitivity could be increased in combined measurement and (iii) whether other factors alter these results.Materials and Methods. We performed a single-center, prospective…

Schlagworte

Alpha-Fetoprotein Diagnosis Tumor Population Association Biomarkers Baltimore China Hepatitis Zeitschrift für Gastroenterologie