CareLit Fachartikel

Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary diseases

J Metzger, A Negm, R Plentz, J Wedemeyer, H Mischak, MP Manns, TO Lankisch · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
977642
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
J Metzger, A Negm, R Plentz, J Wedemeyer, H Mischak, MP Manns, TO Lankisch
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1295993

Zusammenfassung

Aims: Diagnosis of cholangiocarcinoma (CC) and subsequent curative treatment often comes too late due to a lack of reliable early tumor markers. Patients with primary sclerosing cholangitis (PSC) are at risk to develop CC. Thus, a convincing strategy for early CC detection during PSC surveillance is urgently needed. We recently demonstrated that bile proteomic analysis distinguishes CC from non-malignant lesions. Nevertheless, bile collection is invasive. Urine is an attractive diagnostic source because it is less complex than blood and sampling is non-invasive. We hypothesized, that urine proteomic analysis is…

Schlagworte

cholangiocarcinoma diagnosis primary sclerosing cholangitis proteome analysis Blood Cholangitis Tumor Zeitschrift für Gastroenterologie