CareLit Fachartikel
Transport of Gliadin Peptides Into Late Endosomes – an Option to Induce Oral Tolerance in Celiac Disease?
Kristine Anna Scholand, Nico Lübbing, Silvia Rudloff, Klaus-Peter Zimmer · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
977797
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Abstract The mucosal damage in celiac disease is caused by a lack of tolerance towards cereal storage proteins. Strict and lifelong avoidance of these proteins is often felt as annoying and demanding so that the patients expect alternative therapies. One possibility is the induction of tolerance towards the toxic parts of those proteins. The first step in this is antigen presentation at the basolateral membrane of enterocytes. Therefore the antigen has to be transported to MHC II-positive late endosomes. This can be achieved by several methods. One of them is conjugation of the peptide to cholera toxin subunit B…
Schlagworte
Antibodies
Antigen Presentation
Cholera Toxin
Cholera
Choleratoxin
Antigene
Antigens
Atrophy
Breast
Diet
Lead
Avenin
After
Zeitschrift für Gastroenterologie
