Altered reactivity to modulation of cerebral energy metabolism by tDCS in obese. A phosphorus spectroscopy and morphometric study

Aims: Obese have an overall lower brain energy level as normal weighted as shown by phosphorus spectroscopy and changes in brain morphology as shown in VBM. We tested whether tDCS induced transient neuronal energy depletion and the resulting effects on systemic glucose homeostasis and related neuroendocrine mediators differ in obese and normal subjects and whether the altered brain morphology can give us clues about the nature of the altered brain regulation in obese. Methods: In a crossover design (15 healthy males and 15 obese (BMI > 30)) we increased neuronal excitation by anodal tDCS versus sham and examined…