Relationship between Structural Changes and Functional Activity in Emotion Recognition Paradigm in Huntington’s Disease
I Dogan, CF Saß, S Mirzazade, A Kleiman, CJ Werner, F Binkofski, J Schiefer, JB Schulz, NJ Shah, K Reetz · Klinische Neurophysiologie · 2012 · Heft 03
Bibliografische Angaben
Zusammenfassung
Objective: The neural correlates of emotion processing in Huntington’s Disease (HD) have only been investigated in premanifest HD by means of functional MRI (fMRI) focusing on disgust processing1. Using an fMRI paradigm with more emotional valences, we aimed to investigate the functional correlates of emotion perception in manifest HD, while taking account of structural atrophy. Methods: Event-related fMRI and anatomical images were acquired with a 3T Siemens MR Scanner in 14 HD patients (stages2 I-III) and 14 age- and gender-matched healthy controls. An emotion recognition task displayed video-sequences of trai…
