Combined Application of Photofrin II and Ionizing Radiation in an in vitro and in vivo Experiment

The use of photofrin II, which has been approved as a tumor selective photosensitizer, is well established in PDT for tumor treatment. Ionizing irradiation also has a substantial role in tumor therapy. Radiosensitizers are used to increase the efficacy of radiotherapy. In the following work we present the results of in vitro cell survival assay combining the application of Photofrin II and ionizing irradiation. Experiments using several series of cell lines were performed:human bladder cell line (RT 4), colon adenocarcinoma (HT 29) and the glioblastoma cells (U 373 MG) were investgated, with and without of Photo…