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Differences in LOH6q and its prognostic impact on pediatric T-LBL and T-ALL

BR Bonn, M Rohde, M Zimmermann, B Burkhardt · Klinische Pädiatrie · 2012 · Heft 04

Dokument
978046
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
BR Bonn, M Rohde, M Zimmermann, B Burkhardt
Ausgabe
Heft 04 / 2012
Seiten
–
Erschienen: 2012-04-27 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0032-1310473

Zusammenfassung

Introduction: Although survival rates of pediatric T-cell lymphoma (T-LBL) and related T-cell acute lymphoblastic leukemia (T-ALL) patients are about 70–90%, prognosis in case of relapse is very poor. In contrast to the leukemia type of the disease, little is known about the genetic background of the lymphoma type, and recent analyses reveal certain differences between the two manifestations. Methods: DNA of 213 T-LBL and 127 pediatric T-ALL cases, treated according to ALL-BFM (type) treatment strategy, was used for loss of heterozygosity (LOH) analyses. Results: LOH in T-LBL was significantly associated with po…

Schlagworte

T-Lbl T-All Pediatric Prognosis Analyses Differences T-Cell Lymphoma Leukemia Patients About Relapse Klinische Pädiatrie