CareLit Fachartikel

Focal adhesion kinase (FAK) in t(8;21) rearranged acute myeloid leukaemia (AML)

S Prall, J Slack, I Siekmann, N Martinez, O Heidenreich · Klinische Pädiatrie · 2012 · Heft 04

Dokument
978047
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
S Prall, J Slack, I Siekmann, N Martinez, O Heidenreich
Ausgabe
Heft 04 / 2012
Seiten
–
Erschienen: 2012-04-27 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0032-1310483

Zusammenfassung

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase which regulates various cellular processes such as the dynamic of focal adhesion complexes, cell motility, angiogenesis and cell survival. FAK plays a prominent role in various solid tumours, where it is implicated in tumour formation. Increased FAK expression levels generally correlate with their increased invasive potential. Although FAK has been linked to shorter overall survival and enhanced blast migration in AML, the exact role of FAK in haematological diseases remains to be elucidated. Here we show that siRNA mediated knock-down of AML1/MTG8 le…

Schlagworte

Focal Adhesion Kinase Which Various Survival Solid Tumours Increased Expression Levels Target Klinische Pädiatrie