The MRNA cytokine profile of HT-29 cells treated with human DNA isolated from human colon cancer cells
I Fűri, S Spisák, VÁ Patai, F Sipos, B Wichmann, O Galamb, G Valcz, A Kalmár, B Péterfia, K Leiszter, K Tóth, B Barták, Z Nagy, B Molnár, Z Tulassay · Zeitschrift für Gastroenterologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Toll-like receptors recognize specific motifs which are frequently expressed in bacteria, fungi, prokaryotes and viruses. Toll-like receptor 9 (TLR9) can be activated by unmethylated cytosin-guanine dinucleotide containing bacterial or viral DNA, imunoglobulin-DNA complexes and synthetic oligodeoxynucleotide (ODN) sequences. Aims: Our primary aim was to prove that human DNA isolated from a human cancer cell line can activate immune cells via TLR9. Our further aim was to examine changes in the signal transduction pathway downstream of activated TLR9 and to analyze the expression of DNA methyltransfera…
