The effects of folic acid as model methyl donor on epigenetic modification in human CD4+ in vitro

Introduction: Over the past few decades, the incidence of allergic diseases such as asthma has been increasing in children. This increase is been suggested to be of an environment basis and might be triggered by epigenetical modification. Furthermore, there is increasing evidence that different pregnancy supplementation like folic acid and vitamin B12 play a very important role in the development of fetus. Folic acid plays a very important role in DNA repair as well as in DNA methylation in different loci. The goal of this study is to investigate the effect of different concentrations of folic acid in different…