Vagal Modulation in Chronic Musculoskeletal Pain: Mechanisms, Clinical Implications, and Therapeutic Potential
Vladimir Nikolenko, Nataliya Zharova, Elena Mikliaeva, Anastasia Pomelenok, Irina Vostrikova, Ekaterina Ershova, Nikolay Raikh, Tatyana Zharikova, André Pontes-Silva, Yury Zharikov · Aktuelle Rheumatologie · 2026 · Heft 04
Bibliografische Angaben
Zusammenfassung
AbstractFibromyalgia and other chronic musculoskeletal pain conditions are increasingly recognized as disorders involving complex interactions among autonomic, inflammatory, metabolic, and neuropsychological systems. Emerging evidence identifies the vagus nerve as a key regulator in these processes due to its extensive bidirectional communication between the brain and visceral organs. This narrative review synthesizes current knowledge on the functional anatomy of the vagus nerve and its role in modulating pain pathways, immune responses, metabolic regulation, circadian rhythms, and gut–brain interactions. Vagus…
