Urinproteom-Analyse differenziert Cholangiokarzinom von primär sklerosierender Cholangitis und anderen benignen biliären Erkrankungen
J Metzger, A Negm, R Plentz, T Weismüller, J Wedemeyer, T Karlsen, M Dakna, W Mullen, H Mischak, M Manns, T Lankisch · Zeitschrift für Gastroenterologie · 2012 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: Diagnosis and curative treatment of cholangiocarcinoma (CC) often comes too late due to the lack of reliable tumour markers especially in patients with primary sclerosing cholangitis (PSC). We recently introduced bile proteomic analysis for CC diagnosis. Nevertheless, bile collection depends on invasive endoscopic retrograde cholangiography. We therefore evaluated urine proteomic analysis for non-invasive CC diagnosis. Methods: Using capillary electrophoresis mass spectrometry we established a CC-specific peptide marker model based on the distribution of 42 peptides in 14 CC, 13 PSC, and 14 benign biliary…
