Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterized by interferon-gamma-expressing Th1 and IL-17/IL-22-expressing Th1…

Background and aims: Anti-TNF antibodies may cause psoriasiform skin lesions. Currently, the pathogenesis of these lesions is only poorly understood. We analyzed incidence, predictors, histological features and specific treatment options of anti-tumor necrosis factor (TNF)-alpha antibody-induced psoriasiform skin lesions in patients with inflammatory bowel diseases (IBD). Methods: Anti-TNF antibody-treated IBD patients were prospectively screened for anti-TNF-induced psoriasiform skin lesions. Patients were genotyped for IBD- and psoriasis-associated IL23R and IL12B single nucleotide polymorphisms (SNPs). Skin l…