Platelet serotonin drives allergic airway inflammation
D Duerschmied, T Dürk, T Müller, M Grimm, S Reuter, RP Vieira, K Ayata, S Cicko, S Sorichter, DJ Walther, JC Virchow, C Taube, M Idzko · Pneumologie · 2012 · Heft 11
Bibliografische Angaben
Zusammenfassung
Rationale: Serotonin (5-hydroyxtryptamine, 5-HT) appears to be involved in the pathogenesis of allergic airway inflammation (AAI). It is not known however how 5-HT may enhance AAI. Objective: To investigate production and release of 5-HT in asthma. Methods: Tryptophan hydroxylase (TPH) 1-deficient and parachlorophenylalanine- (5-HT-synthesis inhibitor) treated animals were challenged in OVA-alum and HDM-models of AAI. Experiments with bone-marrow chimera, mast cell-deficient animals, platelet transfusion, and a bone marrow dendritic cells (BMDC)-driven model of AAI were performed. 5-HT-levels in bronchoalveolar…
