Associations of HLA-DRB1 genotype with clinical expression of sarcoidosis portuguese patients
S Neves, D Lopes, A Morais, C Carvalho, A Bettencourt, B Leal, P Mota, M Brito, S Torres, S Maia, P Pinho e Costa, B Martins da Silva · Pneumologie · 2012 · Heft 11
Bibliografische Angaben
Zusammenfassung
Introduction: Sarcoidosis is a granulomatous multisystem disorder of unclear etiology that commonly affects the lungs (90%), heart, skin and central nervous system. There is evidence for a strong genetic predisposition. Several studies conducted in different population have reported association between sarcoidosis and HLA (Human Leukocyte Antigen) class I and class II alleles. In Swedish patients Grunewald et al (Respiratory Research, 2010) reported that HLA-DRB1*15 is associated with a chronic course of sarcoidosis while the presence of HLA-DRB1*01 and HLA-DRB1*04 protect against disease. It has been also descr…
