Gender-specific differences in a murine model of non-alcoholic steatohepatitis

Only a fraction of patients with nonalcoholic fatty liver progress to steatohepatitis (NASH). Epidemiological studies revealed gender-specific differences in both prevalence and severity of NASH, however, data are still contradictory. The aim of this study was to assess whether there are gender-specific differences in a dietary model of non-alcoholic steatohepatitis in mice. Methods and Results: Male and female C57BL/6 mice (7 weeks old) were fed with a high-fat diet (HFD), which has been shown to induce NASH that closely resembles pathopyhsiological changes observed in human NASH (Matsuzawa et al. Hepatology 20…