FoxO3 regulates hepatic glucose production

Background and Aims: The FoxO family of Forkhead transcription factors are the key downstream targets of insulin and growth factors regulating cell survival, energy metabolism, and longevity. Under caloric restriction, FoxOs translocate to the nucleus to activate gene expression, while at postprandial stage, they are inactivated through insulin/PI3K/Akt signaling. Mammals harbor four FoxO family members, i.e. FoxO1, FoxO3, FoxO4, and FoxO6. While the studies on FoxO1 confirmed its essential metabolic function, not much is known about FoxO3. Methods: To understand the importance of FoxO3 in the liver in a time- a…