Microrna MIR-352 in early liver regeneration: What role?
SL Lisboa, N Raschzok, A Leder, N Schlüter, M Jörres, S Kolano, A Butter, S Lippert, W Werner, P Neuhaus, IM Sauer · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Objectives: The liver possesses the unique capability to regenerate. Evidence shows that certain miRNAs are differently expressed during liver regeneration. In a previous microarray study, miR-352 was found to be early downregulated following rat partial hepatectomy. The aim of this study is to identify the role played by miR-352 and its putative targets in the early phase of liver regeneration. Materials & Methods: Putative targets of miR-352 were predicted in silico using TargetScan and miRanda. In vitro inhibition and mimicry of miR-352 was performed in primary rat hepatocytes. Proteomic analysis was carried…
