The Role of MicroRNAs in Liver Regeneration

Liver regeneration is multifaceted and well-orchestrated phenomenon which involves complex network of growth factors and cytokines, which themselves are regulated at various levels. Recently, microRNAs (miRNAs) have emerged as one of the robust gene-regulation study tools which may provide distinct insights into high regenerative ability of the liver. Previous studies have shown a crucial role of miRNAs in regulation of various cellular activities such as differentiation, proliferation and apoptosis. MiRNAs are potent post-transcriptional regulators that complementary binds to mRNAs and suppresses translation an…