A novel, microsphere-based prime-boost vaccination model for treatment of hepatocellular carcinoma

Due to disadvantages and limitations of current dendritic cell vaccinations, immunotherapeutic cancer treatment requires novel, innovative vaccination strategies that are able to generate sufficient levels of specific cytotoxic T-cells. Combination of PLGA microsphere-based priming and short-term booster immunization has shown remarkable potential to induce specific CD8+ T-cell levels in vivo and thus could emerge as a suitable tool to overcome the obstacles of CD8+ T-cell based immunotherapy. We wanted to investigate whether this promising approach might be applicable to clinical tumor treatment in vivo, e.g. a…