A murine tumor resection model of endogenously induced intrahepatic cholangiocarcinoma (ICC) with a single, primary tumor and extrahepatic metastases

Intrahepatic cholangiocarcinoma (ICC) is a tumor with worldwide increasing incidence and dismal prognosis. Although surgical resection (R0) of the primary tumor is the only potential curative treatment, most of the patients die because of frequent tumor recurrence and outgrowth of metastases after surgery. Mouse tumor resection models are urgently needed to reflect the clinical relevant situation and investigate novel therapies in the context of ICC. In this study, we wanted to establish a corresponding endogenously induced murine tumor model of resectable, single locus ICC formation. We investigated tumor devel…