A combined bile and urine proteomic test increases diagnostic accuracy of cholangiocarcinoma in patients with biliary strictures of unknown origin

Background: Detection of cholangiocarcinoma (CC) remains a diagnostic challenge particularly in patients with primary sclerosing cholangitis (PSC) who are at risk for CC development. We recently established diagnostic peptide marker models in bile and urine to detect both local and systemic changes during CC progression. Our aim was to combine both models to reach a higher diagnostic accuracy of CC in patients with unknown biliary strictures. Methods: On the basis of bile and urine proteomic analysis by capillary electrophoresis mass spectrometry, a case-control phase II study on 87 patients (36 CC including 5 w…