Dominance of HCV in HBV/HCV co-infected patients is associated with lower quantitative HBsAg and higher serum IP-10 levels
SB Wiegand, J Jaroszewicz, A Potthoff, AA Markova, K Deterding, MP Manns, H Wedemeyer, M Cornberg · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) share similar modes of transmission and co-infection leads to a more progressive liver disease. In the natural course of HBV/HCV co-infection, different hierarchies of viral dominance have been documented based on HBV DNA and HCV RNA quantification. In the majority of cases, HCV seems to be dominant and may suppress HBV replication. Quantification of HBsAg as a correlate for active intrahepatic cccDNA may be useful to understand the interplay between HBV and HCV that may be immune mediated. HCV infection and in particular failure to interferon alfa…
