Levels of anti-double-strand DNA but not antinuclear antibodies are associated with treatment efficacy and adverse outcomes in IBD patients treated with anti-TNF
L Kiss, B Lovász, K Farkas, Z Végh, T Molnár, K Palatka, M Papp, A Mohás, B Szilágyi, S Fekete, M Mandel, P Golovics, P Lakatos · Zeitschrift für Gastroenterologie · 2013 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background & Aims: Treatment of Crohn's disease (CD) by infliximab has been associated with the induction of antinuclear (ANA) and anti-double strand DNA (dsDNA) autoantibodies and in some studies the formation of dsDNA antibodies was associated with lupus-like syndromes.The aim of this study was to analyse the relationship between the development ANA and dsDNA antibodies during anti-tumor necrosis factor (TNF)α therapy and adverse outcome in patients with inflammatory bowel diseases. Methods: Data of 105 (96 CD, age at diagnosis: 27.1 years, duration: 8.2 years, males/females 48/57) patients treated with anti-T…
