The diagnostic accuracy of fecal calprotectin in pouchitis

Introduction: Total proctocolectomy with ileal pouch-anal anastomosis (IPAA) represents the most common surgical procedure for intractable ulcerative colitis (UC), although up to 50% of the patients undergoing surgery will develop pouchitis. The diagnosis of pouchitis requires both pouch endoscopy and biopsy. Searching for non invasive markers which correlate with the degree of the mucosal inflammation is becoming more and more important. The aim of our prospective study was to compare fecal calprotectin in patients with and without pouchitis assessed by clinical, endoscopic and histological scores and to evalua…