BRCA1 like copy number profiles to predict benefit of intensified alkylating chemotherapy in breast cancer

Background: DNA copy-number profiles can identify patients with a defect in BRCA1. We previously showed that patients with a BRCA1-like profile benefit from intensified alkylating (IA) chemotherapy with autologous stem cell transplantation (ASCT). Here we present an independent validation of BRCA1-like profiles to predict benefit of high-dose IA chemotherapy (ifosfamide, epirubicin, carboplatin with ASCT) versus conventional chemotherapy in high risk breast cancer. Methods: Copy number profiles were generated from 117 sporadic high breast cancers and classified to either BRCAlike or non-BRCA-like. We used Fisher…