Expression of G Protein-Coupled Estrogen Receptor (GPER) in endometrial adenocarcinoma and effect of agonist G-1 on growth of endometrial adenocarcinoma cell lines

Fragestellung: The G protein-coupled estrogen receptor (GPER) is involved in non-nuclear estrogen signaling and is expressed in a variety of hormone dependent cancer entities. This study was performed to further elucidate the role of this receptor in endometrial adenocarcinoma. Methodik: We first analyzed GPER expression in 88 endometrial cancer or normal endometrial tissue samples and compared it to those of nuclear steroid hormone receptors. Ergebnisse: In comparison to normal endometrium, GPER mRNA expression was found to be about 6-fold reduced, but still present in endometrial cancer. Expression of this rec…