Regulation of the tumor suppressor PML influences HCC development and growth

Aims: Hepatocellular carcinoma (HCC) is characterised by a very poor prognosis and is associated with high mortality. This accounts for the molecular mechanisms of development of this tumor, which are herterogenous and only incompletely understood. We could previously show that the promyelocytic leukaemia (PML) protein, a nuclear phosphoprotein which has been shown to inhibit cell growth and transformation of tumor cells, plays a role in the regulation of apoptotic factors in hepatocellular carcinoma (HCC). To clarify the clinical implication of PML in HCC, the regulation and expression of PML was analysed in a…