Cholestatic ABCB4-deficient mice reveal depression/anxiety-like behavior
K Hochrath, S Hölter, L Garrett, L Glasl, A Wolff-Muscate, M Hrabé de Angelis, F Lammert, C Stokes · Zeitschrift für Gastroenterologie · 2013 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: Depression is commonly associated with chronic liver disease; however, its causality remains largely unknown (Lee et al. Psychosomatics 2013;54:52 – 9). Quantitative phenotypes are linked to psychiatric disorders, thus genetic studies in mice might help to identify modifier genes that influence behavior. Our aim now was to characterize the behavioral phenotype in the ABCB4-deficient (Abcb4–/– ) mouse, a well-established model for chronic cholestatic liver disease. Methods: We used the Open Field (OF) test, which evaluates spontaneous exploratory drive, reactivity to novelty and emotionality. Specifically,…
