The Pediatric Brain Tumor Preclinical Testing Program: update and perspectives

The Pediatric Brain Tumor Preclinical Testing Program aims at the evaluation of the clinical benefit and of the feasibility of an individualized treatment approach. All available pediatric brain tumors independent of the histological diagnosis from cooperating pediatric oncology centers are included. All tumors are subjected to molecular analyis by gene expression profiling, as well as sequencing in individual cases, allowing for identification of activated signaling pathways. Primary tumor material is transplanted orthotopically into mice. Secondary xenografts will be treated according to the results from the m…