Personalized pediatric oncology: Targeted Therapy and clinical feasibility

Targeted therapy using novel substances such as small molecules and monoclonal antibodies is a promising and probably less toxic therapy compared with conventional chemotherapy. The “Pediatric Targeted Therapy” (PTT) program identifies presence and activity of druggable structures in relapsed tumors on an individual basis for targeted therapies. The PTT-program aims at the evaluation of the feasibility and of the clinical benefit of a personalized medical treatment approach. To this aim, we analyzed 13 molecular targets indicative of a possible specific inhibition in experimental treatment settings (HDAC 2, 5, 8…