Dynamic Contrast-Enhanced Ultrasound (DCE-US) for the differentiation of hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (ICC)

Purpose: Contrast-enhanced ultrasound improves the differentialdiagnosis of focal liver lesions. However the differentiation of HCC and ICC remains a challenge for all imaging techniques. In a prospective pilot study we quantified perfusion kinetics of HCC and ICC. Material and methods: Three-minute Videoclips of CEUS-examinations after Bolusinjection of 1.2 ml Sonovue® were recorded and analyzed with quantification software (VueBox®). Parameters for perfusion quantification of the arterial phase were Rise-Time (RT) and Time-To-Peak (TTP). In addition Mean Transit Time (mTT) was interpreted. Results: Between Nov…