Surface modifications of nanoparticles are crucial for their pro-inflammatory and adjuvant properties in a mouse allergy model
F Alessandrini, V Marzaioli, I Weichenmeier, M Kamml, M Wiemann, R Landsiedel, W Wohlleben, S Eiden, F Meyer, T Kuhlbusch, H Behrendt, J Gutermuth, C Schmidt-Weber · Pneumologie · 2013 · Heft 12
Bibliografische Angaben
Zusammenfassung
Background: In recent years engineered nanomaterials have been widely used in the fields of biomedicine, pharmaceutical, and manufacture industry and introduced into a variety of commercial daily products, such as textile, cosmetics and food packaging. The increasing use of nanomaterials, however, has raised the question whether these nanoparticles may lead to a human health hazard. Aim: To assess the potential health hazard of NPs exposure in allergic airway diseases. Methods: Mice were sensitized by four repetitive intraperitoneal injections of 1 µg OVA/alum over 42 days. Mice were then intratracheally instill…
