Intrahepatic cholestasis-associated ATP8B1 variation underlying protracted cholestatic course of acute hepatitis E virus infection

Introduction: Prolonged cholestatic courses of acute hepatitis E virus (HEV) infection have been reported occasionally [1]. However, as yet no reports have addressed potential genetic factor underlying these rare cholestatic clinical presentations. Although there are no experimental data available so far to support this hypothesis, HEV infection – like other (viral hepatitis) infections – might be assumed to challenge hepatobiliary transporter capacities by repressing expression during cholestatic and inflammatory stress. Clinical Case: A 59-year-old patient presented with severe pruritus and jaundice six weeks…