Role of A20(TNFAIP3) in mediating TNFα-induced pathways activation in mouse hepatoma cell lines and primary hepatocytes

Backround/Aims: The tumor necrosis factor-α (TNFα)/NF-kB pathway is crucial for the regulation of apoptosis and proliferation during chronic liver disease, regeneration, as well as carcinogenesis. Recently, a first mathematical model of TNFα/NF-kB signaling provided an important basis to quantitatively disentangle the complex interplay of pathway components in hepatocytes (Pinna et al., 2012 Front Syst Physiol). However, it is not understood how TNFα activates or inhibits e.g., apoptosis depending on specific environmental conditions. In this work we therefore aim to analyze the impact of signalosome-associated…