Polymorphsims in the farnesoid X receptor modify the risk for spontaneous bacterial peritonitis in cirrhotic patients
HD Nischalke, P Lutz, C Berger, B Langhans, A Hoerauf, F Grünhage, B Appenrodt, F Lammert, J Nattermann, T Sauerbruch, CP Strassburg, U Spengler · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and Aims: The farnesoid X receptor (FXR) is involved in bacterial translocation in mice. In humans with liver cirrhosis, bacterial translocation can result in spontaneous bacterial peritonitis (SBP). We hypothesized that polymorphisms in the FXR gene (NR1H4) might influence the risk for SBP. Methods: We collected blood for genotyping, clinical and laboratory data of 293 cirrhotic patients with ascites and 226 healthy controls. The NR1H4 rs56163822, rs11110390 and rs12313471 polymorphisms were determined on the LightCycler system. Results: In our cohort 115 (39%) patients with liver cirrhosis and ascit…
