Infection of human lung tissue with influenza A and MERS-corona virus
AC Hocke, A Becher, J Knepper, A Peter, G Holland, M Tönnies, T Bauer, P Schneider, J Neudecker, D Muth, C Wendtner, J Rückert, C Drosten, A Gruber, M Laue, T Wolff, N Suttorp, S Hippenstiel · Pneumologie · 2014 · Heft 02
Bibliografische Angaben
Zusammenfassung
Zoonotic respiratory pathogens like influenza A (IAV) or corona viruses causing epidemic and pandemic outbreaks with high fatality rates frequently stresses public health systems worldwide. It remained an open debate whether the efficiency of viral propagation and disease outcome is determined by differences in the receptor dependent cellular tropism of viral subtypes. For IAV, we have shown that independent of human and avian receptor distribution different types of human, avian, and swine viruses almost exclusively replicate in alveolar type II cells. However, the replication rates of the strains showed signif…
